| CAS NO: | 137734-88-4 |
| 包装: | 1mg |
| 市场价: | 2930元 |
| Cas No. | 137734-88-4 |
| 化学名 | (S)-N1-((2S,5S,8S,14S,17S,20S)-14-(((R)-4H-imidazol-4-yl)methyl)-20-carbamoyl-1-(1H-indol-3-yl)-17-isobutyl-8-isopropyl-5,22-dimethyl-3,6,9,12,15,18-hexaoxo-4,7,10,13,16,19-hexaazatricosan-2-yl)-2-((R)-2-amino-3-phenylpropanamido)pentanediamide |
| Canonical SMILES | O=C([C@H](CC(C)C)NC([C@H](C[C@H]1N=CN=C1)NC(CNC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC2=CNC3=CC=CC=C23)NC([C@H](CCC(N)=O)NC([C@@H](CC4=CC=CC=C4)N)=O)=O)=O)=O)=O)=O)=O)N[C@H](C(N)=O)CC(C)C |
| 分子式 | C53H76N14O10 |
| 分子量 | 1069.27 |
| 溶解度 | Soluble to 2 mg/ml in Water |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bombesin has common effects on the gastrointestinal tract and feeding behavior. Bombesin acts on two types of receptors including one with high affinity for neuromedin B and another with high affinity for bombesin and gastrin-releasing peptide (GRP). BIM 187is a new peptide of bombesin while BIM 189 is a potent bombesin antagonis. In vitro: Bombesin stimulates mainly the bombesin high-affinity receptor, and BIM 187 ([D-Phe I ,Leu 8'9 ]litorin-NHe), a new bombesin agonist, stimulates the bombesin/GRP receptor type. [2]. In vivo: To study the mechanism by which bombesin induces satiety, we studied the effect of BIM187 on food intake in rats fed 6 h a day. BIM 187 at 4 μg/kg, reduced food intake at 30 min significantly, but did not change the total 6-h food intake. BIM 189 (10 mg/kg), had no effect on food intake, even at high doses (20 mg/kg). BIM 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by BIM 187 [2]. Clinical trial: Up to now, BIM 187 is still in the preclinical development stage. Reference: |
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