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FLT3-IN-13
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
FLT3-IN-13图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
FLT3-IN-13 (compound 20) 是一种有效的抗白血病topoisomerase II和FLT3双重抑制剂，IC50分别为 2.26 μM 和 2.26 μM。FLT3-IN-13 将细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。FLT3-IN-13具有抗细胞毒性活性，尤其是对白血病。
生物活性

FLT3-IN-13 (compound 20) is a potent and effective antileukemictopoisomeraseIIandFLT3dual inhibitor withIC50values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induceapoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia[1].

IC50& Target

IC50: 2.26 μM (TOPO II), 2.26 μM (FLT3)[1]

体外研究
(In Vitro)

FLT3-IN-13 (compound 20) has strong antiproliferative activity against HL-60 with an IC50of 0.48 ± 0.08 μM[1].
FLT3-IN-13 arrests HL-60 cell cycle at G2/M phase (G1%: 24.76±1.00, S%: 21.26±1.72, G2%: 32.78±2.21, total apoptosis%: 21.36±2.73)[1].
FLT3-IN-13 induces apoptosis of HL-60 with early-apoptosis of 6.13±1.20% and late-apoptosis of 13.06±0.40%[1].
FLT3-IN-13 significantly upregulates P53, TNFα and caspase 3/7 proteins in the HL-60 cell line, and increases the Bax/Bcl-2 ratio[1].

分子量

342.35

Formula

C20H14N4O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.