UPF-523

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UPF-523

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

168560-79-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

AIDA

产品介绍

UPF-523 (AIDA) 是一种刚性 (羧基苯基) 甘氨酸衍生物，是I组代谢型谷氨酸受体(mGlu1a)的高效选择性拮抗剂，IC₅₀值为 214 μM。但 UPF-523 对 II 组 (mGlu2)，III 组 (mGlu4) 受体和离子型谷氨酸受体没有影响。UPF-523 具有研究急性关节炎的潜力。

生物活性

UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group Imetabotropic glutamate receptors(mGlu1a)with anIC₅₀of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis^[1]^[2].

IC₅₀& Target

mGluR1a

214 μM (IC₅₀)

体内研究
(In Vivo)

UPF-523 (0.18 mg/kg; i.p.; 0.5 ml per 100 g) results in a final concentration of 100–150 mM which is below an IC50 of 214 mM^[1].

Animal Model:	Naive male hooded Lister rats (320–350 g)^[1]
Dosage:	0.18 mg/kg
Administration:	I.p.; 0.5 ml per 100 g
Result:	Showed no gross motor abnormalities and normal righting reflexes.

Clinical Trial

分子量

221.21

Formula

C₁₁H₁₁NO₄

CAS 号

168560-79-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.