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[Glp5,(Me)Phe8,Sar9] Substance P(5-11)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
[Glp5,(Me)Phe8,Sar9] Substance P(5-11)图片
CAS NO:77128-69-9
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
DiMe-C7
产品介绍
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) 是一种 Substance P (HY-P0201) 类似物，在大鼠大脑中对神经激肽 1 受体 (NK1R) 的作用与 Substance P (HY-P0201) 大致相等，但作用时间大大延长。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 能选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 还可增加大鼠运动活性，诱导可卡因寻求行为的恢复。
生物活性

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is aSubstance P(HY-P0201) analogue that has approximately the same effects asSubstance P(HY-P0201) onneurokinin 1 receptor(NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats[1][2][3].

体内研究
(In Vivo)

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 μg/side; inject into the ventral tegmental area; single) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢[1]。
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 μg/side; inject into the ventral tegmental area; single) 增加大鼠运动活性，诱导可卡因寻求行为的恢复[2]。

Animal Model:Male Sprague-Dawley rats (300-350 g)[1].
Dosage:2 μg/side
Administration:Inject into the ventral tegmental area; single
Result:Selectively activated mesolimbic and mesocortical dopamine metabolism.
Animal Model:Male Wistar rats (300-350 g)[2].
Dosage:0.5, 1.5, 3 μg/side
Administration:Inject into the ventral tegmental area; single
Result:Significantly increased locomotor activity when at 3 μg/side.
分子量

880.06

Formula

C43H61N9O9S

CAS 号

77128-69-9

Sequence

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

Sequence Shortening

pGlp-QF(-Me)F-Sar-LM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.