C-178

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C-178

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

329198-87-0

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

C-178 是STING的有效和选择性共价抑制剂。C-178 与 Cys91 结合，并抑制小鼠中而非人中由不同的激活剂引起的 STING 反应。

生物活性

C-178 is a potent and selective covalent inhibitor ofSTING. C-178 binds to Cys91 and suppresses theSTINGresponses elicited by distinct bona fide activators in mouse but not human^[1].

IC₅₀& Target

STING^[1]

体外研究
(In Vitro)

C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells^[1].
C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1^[1].
C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-inducedIfnb1expression in mouse bone marrow-derived macrophages^[1].
C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts^[1].

Western Blot Analysis^[1]

Cell Line:	Mouse bone marrow-derived macrophages (BMDMs)
Concentration:	0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
Incubation Time:	1 hour
Result:	Inhibited CMA-induced p-TBK1 expression as a does dependent manner.

RT-PCR^[1]

Cell Line:	Mouse bone marrow-derived macrophages (BMDMs)
Concentration:	1 μM
Incubation Time:	1 hour
Result:	DownregulatedIfnb1expression in BMDMs.

分子量

322.27

性状

Solid

Formula

C₁₇H₁₀N₂O₅

CAS 号

329198-87-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 41.67 mg/mL(129.30 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.1030 mL	15.5149 mL	31.0299 mL
5 mM	0.6206 mL	3.1030 mL	6.2060 mL
10 mM	0.3103 mL	1.5515 mL	3.1030 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。