Venlafaxine

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Venlafaxine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

93413-69-5

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品名称

文拉法辛
Wy 45030

产品介绍

Venlafaxine (Wy 45030) 是口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂。Venlafaxine 具有抗抑郁作用。

生物活性

Venlafaxine (Wy 45030) is an orally active, potentserotonin (5-HT)/norepinephrine (NE)reuptake dual inhibitor. Venlafaxine is an antidepressant^[1].

体外研究
(In Vitro)

Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [^3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a K_iof 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [^3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a K_iof 82 nM^[1].
Venlafaxine inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED₅₀values of 2 and 54 mg/kg, respectively^[1].

体内研究
(In Vivo)

Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA^[1].

Animal Model:	Male Sprague-Dawley rats weighing 180-230 grams^[1]
Dosage:	10, 30, 100 mg/kg
Administration:	IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)
Result:	Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED₅₀values of 12 and 94 mg/kg, respectively.

Clinical Trial

分子量

277.40

Formula

C₁₇H₂₇NO₂

CAS 号

93413-69-5

中文名称

文拉法辛

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.