Trabedersen

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Trabedersen

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

925681-61-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

AP 12009

产品介绍

Trabedersen (AP 12009) 是一种反义寡脱氧核苷酸，可特异性抑制TGF-β2(TGF-beta/Smad)。Trabedersen 可用于研究恶性脑肿瘤和其他过度表达 TGF-β2 的实体瘤，例如皮肤、胰腺和结肠肿瘤。

生物活性

Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibitsTGF-β2(TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressingTGF-β2, such as those of the skin, pancreas and colon^[1]^[2].

体外研究
(In Vitro)

Trabedersen (1-80 μM; 7 days) 减少人胰腺癌细胞系 Hup-T3 中 TGF-β2 的分泌，IC₅₀在低 μM 范围内，明显抑制细胞增殖，并完全阻断迁移胰腺癌细胞^[2]。
Trabedersen 逆转 TGF-β2 介导的胰腺癌细胞免疫抑制^[2]。

Cell Proliferation Assay^[2]

Cell Line:	Hup-T3 cells
Concentration:	1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM, 60 μM, 80 μM
Incubation Time:	7 days
Result:	Inhibited cell proliferation, and completely blocked migration of pancreatic cancer cells.

体内研究
(In Vivo)

Trabedersen（初始负荷剂量为 50 mg/kg ，随后每周 3 次 16 mg/kg；i.p.）可显著降低转移性胰腺癌原位小鼠模型中的肿瘤生长、淋巴结转移和血管生成^[2]。

Animal Model:	Eight-week-old male athymic nude mice (BALB/Cnu /nu) bearing human pancreatic cancer cells^[2].
Dosage:	Initial loading dose of 50 mg/kg bodyweight followed by 16 mg/kg three times a week.
Administration:	Intraperitoneal (i.p.) injection; three times a week; for 27 days
Result:	Significantly reduced tumor growth, lymph node metastasis and angiogenesis.

分子量

5770.75

CAS 号

925681-61-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.