Araliadiol 是从Aralia cordataThunb 的叶子中分离出来的一种聚炔化合物。Araliadiol 抑制 MCF-7 细胞生长，IC50值为 6.41 μg/mL。
| 生物活性 | Araliadiol is a polyacetylenic compound isolated from the leaves ofAralia cordataThunb.Araliadiol inhibits MCF-7 cells growth with anIC50value of 6.41 μg/mL[1]. |
| IC50& Target | IC50: 6.41 μg/mL (MCF-7 cells growth)[1] |
体外研究
(In Vitro) | Araliadiol (20-80 μM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition[1].
Araliadiol (20-80 μM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D3and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)[1].
Cell Cycle Analysis[1] | Cell Line: | MCF-7 cells | | Concentration: | 20 μM, 40 μM, and 80 μM | | Incubation Time: | 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours | | Result: | The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %). |
Western Blot Analysis[1] | Cell Line: | MCF-7 cells | | Concentration: | 20 μM, 40 μM, and 80 μM | | Incubation Time: | 48 hours | | Result: | Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D3and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1). |
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| 来源 | - Plants
- Araliaceae
- Aralia cordataThunb.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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