Melitracen

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Melitracen

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

5118-29-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Melitracene
N 7001
Trausabun

产品介绍

Melitracen (Melitracene) 是一种具有口服活性的三环抗抑郁药，也是一种具有激活特性的躁狂症药物。Melitracen 对³H-5-HT 和¹⁴H-5-HT 具有抑制作用，其IC₅₀值分别为 670 nM 和 5500 nM。Melitracen 可用于抑郁和焦虑的研究。

生物活性

Melitracen (Melitracene) is an orally activetricyclic antidepressantand it is also a bipolar thymoleptic with activating properties. Melitracen inhibits³H-5-HT and¹⁴H-5-HT withIC₅₀s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety^[1]^[2].

IC₅₀& Target

IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT)^[2]

体外研究
(In Vitro)

Melitracen (0-10 μM; 10 min) inhibits³H-5-HT in synaptosomes and¹⁴H-5-HT in blood platelets^[2].

Cell Viability Assay^[2]

Cell Line:	Synaptosomes and blood platelets from male albino rats
Concentration:	0-10 μM
Incubation Time:	10 min
Result:	Inhibited³H-5-HT in synaptosomes and¹⁴H-5-HT in blood platelets with IC₅₀s of 670 nM and 5500 nM, respectively.

体内研究
(In Vivo)

Melitracen (10-90 mg/kg; p.o. once daily for 3 months) affects behavior, weight and growth of rats^[1].

Animal Model:	Male and female Wistar rats^[1]
Dosage:	10, 30 and 90 mg/kg
Administration:	Oral gavage; 10-90 mg/kg daily; for 3 months
Result:	Showed aggressive behaviour, excitability, body and livers weight gain, and livers slight atrophic with increasing dose to rats.

Clinical Trial

分子量

291.43

Formula

C₂₁H₂₅N

CAS 号

5118-29-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.