DolaSTATin 10 是一种多肽，可以抑制微管蛋白聚合，显示除抗有丝分裂的活性。

Dolastatin 10 is a potent antimitotic peptide that inhibits tubulin polymerization.

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare?Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50?values of 10?5-10?6?μg/mL (10?2-10?3?nM) against a similar minipanel of human cell lines[1]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[2].

110417-88-4

C42H68N6O6S

785.09

NSC 376128;尾海兔素10;DLS 10

DMSO:100 mg/mL (127.37 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years