6-Mercaptopurine 是一种具有免疫抑制特性的抗代谢物抗肿瘤剂。它通过抑制嘌呤代谢来干扰核酸合成，通常与其他药物联合用于白血病的治疗或缓解维持计划。

Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

磷酸核糖焦磷酸酰胺转移酶是嘌呤合成的限速酶,可改变RNA和DNA的合成和功能。Mercaptopurine通过抑制磷酸核糖焦磷酸酰胺转移酶而抑制嘌呤核苷和代谢,能够干扰核苷酸的互变和糖蛋白的合成。

50-44-2

C5H4N4S

152.18

6-MP;Mercaptopurine;6-巯基嘌呤,乐疾宁;6-巯基嘌呤

DMSO:28 mg/mL (184 mM)
Ethanol:<1 mgml
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years