Anamorelin 是新型ghrelin receptor激动剂，根据FLIPR 检测，得到其EC50=0.74 nM。

Anamorelin is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).

Anamorelin(ANAM) is a potent and highly specific ghrelin receptor agonist

Anamorelin(ANAM) showed significant agonist and binding activity on the ghrelin receptor, and stimulated GH release in vitro.?In rats, ANAM significantly and dose-dependently increased FI and BW at all dose levels compared with control, and significantly increased GH levels at 10 or 30 mg/kg doses.?Increases in GH and IGF-1 levels were observed following ANAM administration in pigs.

249921-19-5

C31H42N6O3

546.7

ONO-7643;RC-1291;阿拉莫林

DMSO:100 mg/mL (182.92 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years