Coumestrol 是一种大豆产品中存在的植物雌激素。它抑制ES2细胞增殖的IC50值为50 μM。它可用于癌症，神经障碍和自身免疫疾病的研究。

Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.

Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation [1]. Coumestrol inhibits viability and invasion and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of the proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2, and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner [2].

479-13-0

C15H8O5

268.22

考迈斯托醇;拟雌内酯

DMSO:25mg/mL (93.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years