Hemin 是一种含铁卟啉和血红素加氧酶 (HO)-1 诱导剂。

Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.

Hemin treatment decreased cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, we observed enhancement of anti-proliferative effects of statins by hemin, documented as decreased cell proliferation after 48 h of co-treatment[1][2].

In vitro effects of various statins and hemin, a heme oxygenase inducer, on cell proliferation were evaluated in PA-TU-8902, MiaPaCa-2 and BxPC-3 human pancreatic cancer cell lines. The effect of statins on heme oxygenase activity was assessed and heme oxygenase-silenced cells were used for pancreatic cancer cell proliferation studies. Cell death rate and reactive oxygen species production were measured in PA-TU-8902 cells, followed by evaluation of the effect of cerivastatin on GFP-K-Ras trafficking and expression of markers of invasiveness, osteopontin (SPP1) and SOX2[1].

16009-13-5

C34H32ClFeN4O4

651.95

氯化血红素;Hemin chloride

DMSO:6.5 mg/mL (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years