Mezigdomide 是一种 cereblon E3 泛素连接酶调节药物 ，具有抗骨髓瘤活性，以分子胶的方式作用。

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.

CC-92480-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. CC-92480 is effective in CC-4047, CC-5013, and CC-220-resistant cell lines.

2259648-80-9

C32H30FN5O4

567.61

CC-92480

DMSO:5 mg/mL (8.81 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years