NSC232003 是高效的UHRF1抑制剂，能够抑制 DNA 甲基化，并破坏 DNMT1/UHRF1 相互作用。

NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.

NSC232003 is an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors.NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance.

1905453-18-0

C6H7N3O3

169.14

H2O:17 mg/mL (100.51 mM),Need ultrasonic and warming
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years