(R)-MG-132 是一种 MG-132 的对映异构体，是一种Proteasome" style="display: inline; color: #c13a36">蛋白酶体 (Proteasome) 抑制剂，细胞毒性比 MG-132 弱，是一种比 MG-132 更有效的Proteasome抑制剂。

(R)-MG-132 is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.

(R)-MG-132 is studied as a potential chymotrypsin-like inhibitor, trypsin-like, and peptidylglutamyl peptide hydrolyzing activities of proteasome. MG-132 and (R)-MG-132 are investigated for inhibition of ChTL, trypsin-like (TL) and peptidylglutamyl peptide hydrolyzing (PGPH) activities of purified 20S proteasomes isolated from human erythrocytes.For (R)-MG-132, the IC50s of 0.22 μM, 34.4 μM, and 2.95 μM for ChTL, TL, and PGPH, respectively. For MG-132, the IC50s of 0.89 μM, 104.43 μM, and 5.7 μM for ChTL, TL, and PGPH, respectively.

1211877-36-9

C26H41N3O5

475.62

(S,R,S)-(-)-MG-132;Z-Leu-D-leu-leu-al;N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺

DMSO:100 mg/mL (210.25 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years