ASP2453是选择性的KRas G12C共价抑制剂，抑制Son of Sevenless介导的KRas G12C和Raf之间的相互作用，IC50为40 nM。
产品描述
ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
Cas No.
2241719-73-1
分子式
C40H48F3N7O4
分子量
747.85
储存和溶解度
DMSO:250 mg/mL (334.29 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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