K-Ras G12C-IN-4 是一种 KRas G12C 共价抑制剂。

K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C..

Administration of K-Ras G12C-IN-4 for 4 hours inhibits MAPK signaling (p-ERK) in MIA PaCa-2 cells with IC50 of 0.219 μM[1]. In the CellTiter-Glo assay of MIA PaCa-2 cells, the use of K-Ras G12C-IN-4 for 72 hours inhibited its cell viability with IC50 of 0.067 μM[1].

2376328-55-9

C31H33ClN4O4

561.07

DMSO:50 mg/mL (89.115 mM),ultrasonic and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years