Zapnometinib 是 CI-1040 的活性代谢物，是一种MEK抑制剂，IC50值为 5.7 nM，有抗流感病毒的抗病毒和抗菌活性。

zapnometinib is a MEK inhibitor.

Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1].Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2[1].

Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg?h/mL in mice by i.v. or oral route, respectively[1].Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1].

303175-44-2

C13H7ClF2INO2

409.55

2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid;PD0184264;ATR-002;3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid

DMSO:60 mg/mL (146.50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years