Menadione sodium bisulfite 是可以诱导急性氧化应激的试剂，可用作植物防御活化剂，具有抵抗病菌的作用。

Menadione sodium bisulfite(MSB, also known as vitamin K3),is used clinically in China to treat hemorrhagic diseases caused by vitamin K deficiency and globally as a vitamin K supplement.

MSB inhibited Aβ42 amyloid formation in a dose dependent manner, delayed the secondary structural conversion of Aβ42 from random coil to ordered β-sheet, and attenuated the ability of Aβ42 aggregates to disrupt membranes; moreover, the quinone backbone rather than lipophilicity is esstial for the inhibitory effects of MSB. Next, in cells expressing a pathogenic APP mutation (Osaka mutation) that results in the formation of intraneuronal Aβ oligomers, MSB inhibited the intracellular aggregation of Aβ. Moreover, MSB treatment significantly extended the life span of Caenorhabditis elegans CL2120, a strain that expresses human Aβ42. Together, these results suggest that MSB and its derivatives may be further explored as potential therapeutic agents for the prevention or treatment of Alzheimer's disease(AD)[1].

130-37-0

C11H9NaO5S

276.24

Sodium menadione bisulfite;亚硫酸氢钠甲萘醌;Menadione sodium bisulfite;Vitamin K3 sodium bisulfite

DMSO:36 mg/mL (130.32 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years