Valecobulin hydrochloride 是 S516 的缬氨酸前体药和血管阻断剂。Valecobulin hydrochloride对β-微管蛋白聚合有强效的抑制作用，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。

Valecobulin hydrochloride is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.

In various human tumor xenograft models,Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; In male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy [1].

1240321-53-2

C26H29ClN6O5S

573.06

CKD-516 hydrochloride

DMSO:125 mg/mL (218.13 mM),Need ultrasonic
H2O:50 mg/mL (87.25 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years