Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

1962925-28-5

C23H29Cl2FN4O4

515.41

CCT 241533 dihydrochloride

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years