ATB107 hydrochloride 是吲哚-3-甘油磷酸合酶 (IGPS) 的新型有效抑制剂, 其 KD 值为 3 μM。

ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM.

The minimum inhibitory concentration (MIC) of ATB107 hydrochloride is 0.1 μg/mL for M. tuberculosis H37Ra. ATB107 hydrochloride also has high activity against M. tuberculosis H37Rv, with an MIC of 0.1 μg/mL. All 50 fully susceptible clinical isolates tested are susceptible to ATB107 at 1 μg/mL; of these, 41 (82%) are susceptible to ATB107 at 0.1 μg/mL. The results also show that 67 (83.8%) multidrug-resistant TB (MDR-TB) isolates are susceptible to ATB107 hydrochloride at 1 μg/mL, and 25 (31.3%) isolates are susceptible to ATB107 hydrochloride at 0.1 μg/mL. Results show that the binding ability of ATB107 hydrochloride is well correlated with its concentrations. At the highest concentration of 200 μg/mL, ATB107 hydrochloride can inhibit cell proliferation, with cell survival of about 60%. With the lower concentration of 50 μg/mL, cell survival is more than 80% for ATB107 hydrochloride[1].

T10394L

C21H29ClN8

428.96

ATB107 hydrochloride(455325-51-6 Free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years