Anserine 是 Carnosine 的甲基化形式，是口服具有活性的天然二肽，存在于脊椎动物的骨骼肌。它不会被血清肌肽酶裂解，能够作为生化缓冲液，螯合剂，抗糖化剂和抗氧化剂。它能够改善阿尔茨海默氏病模型小鼠的记忆功能。

Anserine is a dipeptide containing β-alanine and histidine, which can be found in the skeletal muscle and brain of mammals and birds. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice.

Intraperitoneal administration of specific doses of anserine to hyperglycemic rats reduced hyperglycemia and plasma glucagon concentrations, whereas thioperamide eliminated the effects of anserine. Intraduodenal injection of 0.1 mg anserine to anesthetized rats after laparotomy suppressed sympathetic nerve activity and enhanced activity of the vagal gastric efferent. In addition, oral administration of anserine reduced blood glucose levels during oral glucose tolerance testing in humans. These results suggest the possibility that anserine might be a control factor for blood glucose, and that histaminergic nerves may be involved in the hypoglycemic effects of anserine

584-85-0

C10H16N4O3

240.26

L-Anserine;L-鹅肌肽

DMSO:Insoluble
H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years