AGX51 是 DNA 结合蛋白抑制剂 (ID) 的拮抗剂。 AGX51 治疗导致泛 Id 降解、细胞周期停滞和细胞死亡。

AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.

AGX51 inhibits the Id1-E47 interaction. AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization. AGX51 may have utility in the management of multiple diseases[1].

330834-54-3

C27H29NO4

431.52

Ethanol:95 mg/mL (220.15 mM),Need ultrasonic
DMSO:95 mg/mL (220.15 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years