Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm

1260635-77-5

C18H22N2O5

346.38

coumarin-SAHA;coumarin-Suberoylanilide Hydroxamic Acid

DMSO:5 mg/mL
DMF:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years