Acarbose 是一种具有口服具有活力 α-葡萄糖苷酶 (alpha-Glucosidase) 抑制剂 (IC50=11 nM)，是一种降糖药。它能提高磺脲类药物或胰岛素的降血糖作用。

Acarbose is an inhibitor of α-Glucosidases with antihyperglycemic activity.

Acarbose binds to and inhibits α-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. In addition, acarbose inhibits pancreatic α-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines.

Cell viability is determined using the MTT assay. Cells are seeded in 24-well culture plates at a density of 2×104 cells/well, incubated for 48 h, treated with acarbose at varying concentrations (0.5, 1.0, 2.0, 3.0, and 5.0 μM) for 24 h; or pre-treated with TNF-α (20 ng/mL) for either 24 h or 48 h to evaluate the dose-dependent effects of acarbose on VSMC growth and viability, cultured with 0.5 mg/mL MTT at 37°C in a humidified atmosphere of 5% CO2 for another 4 h, and solubilized with isopropanol. The viable cell number varies directly with the concentration of formazan product measured spectrophotometrically at 563 nm.

56180-94-0

C25H43NO18

645.6

阿卡波糖;BAY g 5421;Acarbose

DMSO:64.5 mg/mL (100 mM)
H2O:64.5 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years