mIDH1-IN-1 (compound 43) 是一种有效且选择性的mIDH1(异柠檬酸脱氢酶 1 突变体)抑制剂，其IC50为 961.5 nM。在 HT1080 细胞中，mIDH1-IN-1 能有效抑制细胞内2-HG(2-hydroxyglutarate) 的产生，其EC50为 208.6±8.0 nM。 mIDH1-IN-1 对 IDH1 突变体 U-87 细胞具有显著的抗增殖活性，其IC50为 41.8 nM。 mIDH1-IN-1 是一种抗肿瘤剂，可用于 IDH1 突变实体瘤的研究。

mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC 50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC 50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC 50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research [1].

2757155-96-5

C25H27N3O5

449.5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years