H-Tyr(3-I)-OH 是酪氨酸羟化酶抑制剂和甲状腺激素 的中间体。

H-Tyr(3-I)-OH is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones

3-iodo-L-tyrosine, at high concentration, is able to induce the intracellular aggregation of αSyn, and death of TH-positive neurons. These phenomena are considered as hallmarks of PD

Twenty mice were infused with H-Tyr(3-I)-OH into the dorsal striata.?Mice were anesthetized with ketamine (50 mg/kg IP) and xylazine (5mg/kg IP,) and placed in a David Kopf stereotaxic apparatus.?Vehicle and H-Tyr(3-I)-OH solution (0, 1 and 10μM H-Tyr(3-I)-OH dissolved in 0.9% NaCl with 0.001% acetic acid) was slowly injected (5 μl volume) with a blunted 30-gauge cannula at the following coordinates of the left dorsal striata with respect to bregma: AP= +0.86, L= +1.6, and V= -3.5 mm.

70-78-0

C9H10INO3

307.09

3-Iodo-L-tyrosine;3-碘-L-酪氨酸;H-Tyr(3-I)-OH

DMSO:Insoluble
H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years