TPB15 是一种口服有效的Hh(Hedgehog) 信号抑制剂。TPB15 显著诱导 MDA-MB-468 细胞周期阻滞和凋亡。TPB15 阻断Smo(Smoothened) 转位到纤毛中，降低 Smo 蛋白和 mRNA 表达。TPB15 可抑制下游调控因子胶质瘤相关癌基因1 (Gli1) 的表达。TPB15 具有较好的抗肿瘤活性和较低的毒性。

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 ( Gli1 ). TPB15 shows good anti-tumor activity with low toxicity [1].

2170347-69-8

C18H9Cl4N5O

453.11

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years