FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR 167653 , an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.

FR 167653 (32 mg/kg;?i.h.;?24-48 hours) significantly decreases the extent of acute tubular necrosis.

158876-66-5

C24H20FN5O6S

525.51

FR 167653 sulfate;FR 167653

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years