MMV666810 是一种类似于 MMV390048 的2-氨基吡嗪，5.94 nM的 MMV666810 对无性寄生虫有效。与早期相比，MMV666810 对晚期配子体细胞的选择性是早期的3.3倍（早期配子体:IC50603 ± 88 nM; 晚期配子体:IC50179 ± 8 nM）。

MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM. MMV666810 is more active on late-stage gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC 50 603 ± 88 nM; late-stage gametocyte: IC 50 179 ± 8 nM).

1450666-97-3

C23H21F3N4O2

442.43

MMV666810

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years