AT2 receptor agonist C21 is a druglike selective agonist of angiotensin II AT2 receptor(Ki of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively).

AT2 receptor agonist C21, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat. Which induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats. And it lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1].

477775-14-7

C23H29N3O4S2

475.62

AT2 receptor agonist C21

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years