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MMAF Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MMAF Hydrochloride图片
CAS NO:1415246-68-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

Description: Monomethyl auristatin F (MMAF) HCl is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.

References: Kostova V, Dransart E, Azoulay M, Brulle L, Bai SK, Florent JC, Johannes L, Schmidt F. Targeted Shiga toxin-drug conjugates prepared via Cu-free click chemistry. Bioorg Med Chem. 2015 Nov 15;23(22):7150-7.

Related CAS: 1799706-65-2 (sodium); 1415246-68-2 (HCl); 745017-94-1 (free base)

纯度:≥98%

CAS:1415246-68-2