| CAS NO: | 105956-97-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 365.79 |
|---|---|
| Formula | C17H17ClFN3O3 |
| CAS No. | 105956-97-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: <1 mg/mL |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: (+-)-7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride InChi Key: BMACYHMTJHBPOX-UHFFFAOYSA-N InChi Code: InChI=1S/C17H17ClFN3O3.ClH/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9;/h5,7-9H,1-4,6,20H2,(H,24,25);1H SMILES Code: c1c2c(c(c(c1F)N3CCC(C3)N)Cl)n(cc(c2=O)C(=O)O)C4CC4.Cl |
| Synonyms | CI-960, PD-127391, AM-1091; CI960, PD127391, AM1091; CI 960, PD 127391, AM 1091; Clinafloxacin hydrochloride; Clinafloxacin HCl; UNII-G17M59V0FY; CI 960 HCl. |
| In Vitro | In vitro activity: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Clin Pharmacol. 1999 Nov;39(11):1143-50; Antimicrob Agents Chemother. 1998 Nov;42(11):2810-6. |
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