Parsaclisib HCl (INCB-50465; INCB-050465), the hydrochloride salt of Parsaclisib, is a novel and potent PI3Kδ inhibitor which inhibits PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. INCB050465 synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. It displays potent activity with IC50 ranging from 0.2 to 2 nM. In addition, INCB050465 blocks the proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM) and can slow tumor growth in the Pfeiffer model of DLBCL in vivo.

纯度：≥98%

CAS：1995889-48-9