AR-12456 is a trapidil analogue. AR-12456 protects against serum hyperlipidemia in guinea pigs. AR-12456 has a strong antilipidemic action in guinea pigs fed a cholesterol-rich diet. References: Corsini A, Grignaffini P, Beitz J, Mest H, Bellosta S, Fumagalli R, Paoletti R. Effect of trapidil derivative AR 12456 on intracellular cholesterol homeostasis in human hepatoma cell line Hep G2. Cytotechnology. 1993 Jan;11(Suppl 1):S15-7. doi: 10.1007/BF00746043. PubMed PMID: 22358683. 2: Corsini A, Grignaffini P, Beitz J, Mest HJ, Bellosta S, Fumagalli R, Paoletti R. Effect of trapidil derivative AR 12456 on intracellular cholesterol homeostasis in human hepatoma cell line Hep G2. Cytotechnology. 1993;11 Suppl S15-7. PubMed PMID: 7763747. 3: Beitz J, Corsini A, Bellosta S, Bernini F, Fumagalli R, Mest HJ, Paoletti R. Influence of trapidil and derivatives on cholesterol synthesis and esterification in cultured cells. Pharmacol Res. 1991 Oct;24(3):235-42. PubMed PMID: 1956868. 4: Beitz J, Riedel A, Beitz A, Giessler C, Kittel A, Mest HJ. The trapidil derivative AR 12456 protects against serum hyperlipidemia in guinea pigs. J Lipid Mediat. 1991 Mar-Apr;3(2):177-86. PubMed PMID: 1665714. 5: Corsini A, Beitz J, Granata A, Fumagalli R, Mest HJ, Paoletti R. Trapidil derivatives and low density lipoprotein metabolism by human skin fibroblasts and by human hepatoma cell line Hep G2. Pharmacol Res. 1989 Sep-Oct;21(5):521-31. PubMed PMID: 2594609. 6: Markwardt F, Nilius B. Effects of trapidil-derivatives on calcium channel currents in isolated ventricular cells from mice. Naunyn Schmiedebergs Arch Pharmacol. 1988 Apr;337(4):454-8. PubMed PMID: 2457174. 7: Heinroth-Hoffmann I, Hauser A, Taube C, Mest HJ. Effects of trapidil and trapidil derivatives on arachidonic acid and prostaglandin endoperoxide analogue U 46619-induced blood pressure changes in rats. Biomed Biochim Acta. 1988;47(10-11):S145-8. PubMed PMID: 3248102. 8: Beitz J, Corsini A, Granata A, Fumagalli R, Mest HJ, Paoletti R. Effect of derivatives of trapidil on the expression of LDL receptors. Biomed Biochim Acta. 1988;47(10-11):S153-6. PubMed PMID: 2854727. 9: Heinroth-Hoffmann I, Hauser A, Mest HJ. Inhibition of thromboxane A2 production by trapidil and trapidil derivatives in the arachidonic acid-injected rat. Prostaglandins Leukot Med. 1987 Dec;30(2-3):87-92. PubMed PMID: 2827194. 10: Block HU, Hoffmann-Heinroth I, Taube C, Niebisch M, Mest HJ. Inhibition of thromboxane B2 formation of blood platelets by trapidil and other s-triazolo(1,5-a)pyrimidine derivatives. Prostaglandins Leukot Med. 1987 Dec;30(2-3):77-86. PubMed PMID: 2827193. 1 Dienel A, Andreas K, Schmidt J. Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility. Biomed Biochim Acta. 1985;44(5):767-71. PubMed PMID: 4062922. 12: Hering S, Bodewei R, Schubert B, Krause EG, Wollenberger A. Trapidil and other 5-triazolo-(1, 5-alpha)-pyrimidine derivatives as calcium channel blockers in 108CC5 cells. Biomed Biochim Acta. 1985;44(5):K37-41. PubMed PMID: 2415119. Langner A, Melzig MF, Kempa S, Krause A. [The use of lymphocyte cultures for the investigation of drug biotransformation]. Pharmazie. 1995 Feb;50(2):130-8. German. PubMed PMID: 7700967.

纯度：≥98%

CAS：100557-04-8