生物活性
Finasteride是合成的II型5α-还原酶抑制剂。该酶将睾丸激素转化为二氢睾丸激素(DHT)。
靶点信息
化学数据
| 目录号 | A10387 |
| M. Wt | 372.5 |
| Formula | C23H36N2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 98319-26-7 |
| Synonyms | Proscar, Propecia |
| SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C |
溶解度
| In vitro | DMSO | 67 mg/mL (179.85 mM) |
| Water | Insoluble |
| Ethanol | 67 mg/mL (179.85 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.85 mL | 134.23 mL | 268.46 mL |
| 0.5 mM | 5.37 mL | 26.85 mL | 53.69 mL |
| 1 mM | 2.68 mL | 13.42 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
*The above data is based on the productmolecular weight 372.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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