Background:

Mebhydrolin is a specific histamine H1 receptor antagonist.

Mebhydrolin is a specific histamine H1-receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study[2].

[1]. O’Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7. [2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.