Ciraparantag是凝血酶和Xa的抑制剂，除了VKAs以外对所有的凝血剂都有对抗作用
CAS：1438492-26-2
分子式：C22H48N12O2
分子量：512.7
纯度：98%
存储：Store at -20°C

Background:

Ciraparantag is a thrombin and factor Xa inhibitors as well as to heparin-based anticoagulants through non-covalent hydrogen bonding and charge interactions. It is reported to antagonize the effects of all coagulants except VKAs and agratroban. [1][2]

[1]. Arundhati Das et al. Novel antidotes for target specific oral anticoagulants. Exp Hematol Oncol, 2015, 4: 25. [2]. Tiffany Y Hu et al. Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, and idarucizumab. Vasc Health Risk Manag, 2016, 12: 35-44.