Zaurategrast ethyl ester sulfate (CDP323 sulfate) 是 CT7758 的乙酯前药，是 α4β1/α4β7 整联蛋白拮抗剂，可用于治疗炎症和自身免疫疾病。
CAS：1214261-78-5
分子式：C28H29BrN4O3.1/2H2O4S
分子量：647.54
纯度：98%
存储：Store at -20°C

Background:

Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2]. α4β1/α4β7 integrin[1]

Zaurategrast ethyl ester sulfate (CDP323 sulfate), an ethyl ester prodrug of CT7758, shows some improvements in increasing mass transfer[1].

[1]. Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91. [2]. Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases• Drug Discov Today. 2007 Jul;12(13-14):569-76.