LDN 0088050 是一种选择性的脂肪酸结合蛋白 (AFABP, FABP4) 抑制剂，FABP4、FABP3 的 Ki 值分别为 0.29、1.3 μM. LDN 0088050 结合 FABP4 的Kd 值为 2.05 μM。
CAS：353484-30-7
分子式：C19H18BrNO2
分子量：372.26
纯度：98%
存储：Store at -20°C

Background:

LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1]. Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1]Kd: 2.05 μM (FABP4)[1]

LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1].

[1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. Bioorg Med Chem. 2016 Sep 15;24(18):4310-4317.