ORM-10962 是有效的、高度选择性的钠钙交换器 (NCX) 抑制剂，对正向反向模式抑制的 IC50 值分别为 67 nM 和 55 nM。
CAS：763926-98-3
分子式：C27H29N3O4
分子量：459.54
纯度：98%
存储：Store at -20°C

Background:

ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively[1][2]. NCX[1][2].

[1]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041. [2]. Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.