RTC-30 是一种具有抗癌效力的优化吩噻嗪。RTC-30 含有羟基化接头 (N),其增加了口服生物利用度。
CAS:1423077-95-5
分子式:C24H23F3N2O4S
分子量:492.51
纯度:98%
存储:Store at -20°C
Background:
RTC-30 is an optimized phenothiazine with anti-cancer potency. RTC-30 contains a hydroxylated linker (N) that confers increased oral bioavailability[1].
RTC-30 (0-40 μM; 48 hours) inhibits H1650 lung adenocarcinoma cell growth with an GI50 of 15 μM[1]. Cell Viability Assay[1] Cell Line: H1650 lung adenocarcinoma cells
[1]. Kastrinsky DB, et al. Reengineered tricyclic anti-cancer agents. Bioorg Med Chem. 2015 Oct 1;23(19):6528-34.