Trimethoprim 3-oxide 为一种三甲氧苄二氨嘧啶的初级代谢物。
CAS：27653-67-4
分子式：C14H18N4O4
分子量：306.32
纯度：98%
存储：Store at -20°C

Background:

Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim[1].

Trimethoprim 3-oxide is the primary metabolite of trimethoprim[1].Trimethoprim 3-oxide (3-NO-TMP) is converted from trimethoprim by CYP1A1 and CYP1B1 with highest rates in human liver microsomes (HLMs). The CYP1A inhibitor α-Naphthoflavone inhibits Trimethoprim 3-oxide formation, however, other competitive P450 inhibitors has no obvious inhibition on the formation[1].

[1]. Goldman JL, et al. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep;43(9):1372-80.