SJB3-019A 是一种有效的新型 USP1 抑制剂，在促进 K562 细胞中 ID1 降解和细胞毒性方面的作用是 SJB2-043 的 5 倍，IC50 为 0.0781 μM。
货号:ajcx11214
CAS:2070015-29-9
分子式:C16H8N2O3
分子量：276.25
溶解度:≥ 10.85mg/mL in DMSO with gentle warming
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].

Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].

SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].

参考文献:
[1].  Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.