STING agonist-12 (Compound 53) 是一种口服有效的人 STING 激活剂，EC50 为 185 nM。
货号:ajcx39276
CAS:2259624-71-8
分子式:C25H19ClF4N2O2
分子量：490.88
溶解度:DMSO : 250 mg/mL (509.29 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].STING agonist-12 is not active at mouse STING[1].

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

[1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869.