SI-2 (EPH 116 hydrochloride) 是一种非常有前景的 SRC-3 抑制剂 (PPI)，对乳腺癌细胞死亡的 IC50 值为 3-20 nM。 SI-2（EPH 116 盐酸盐）具有大大改善的毒性和药代动力学特征，具有可接受的口服可用性。
货号:ajcx27316
CAS:N/A
分子式:C15H15N5.HCl
分子量：301.78
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID:27084884