Background:

Mitragynine-d₃(CRM) is a certified reference material intended for use as an internal standard for the quantification of mitragynine by GC- or LC-MS. Mitragynine is categorized as an opioid.^1,2Mitragynine and its derivatives have been identified in products sold as incense.³This product is intended for research and forensic applications.

1.Matsumoto, K., Mizowaki, M., Suchitra, T., et al.Central antinociceptive effects of mitragynine in mice: Contribution of descending noradrenergic and serotonergic systemsEur. J. Pharmacol.317(1)75-81(1996) 2.Takayama, H., Ishikawa, H., Kurihara, M., et al.Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligandsJ. Med. Chem.45(9)1949-1956(2002) 3.Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y.Survey of current trends in the abuse of psychotropic substances and plants in JapanLeg. Med. (Tokyo)13(3)109-115(2011)